Civilians in eastern Ukraine are facing increasing hardships, with wrecked infrastructure and limited access to power and water supplies, the UN says.
UN humanitarian chief John Ging said "immediate action" was needed to halt the conflict and prevent the situation from putting more people in danger.
At a UN Security Council meeting Russia blamed Ukraine for the hardships, but the UK said it was Russia's fault.
The UN estimates that 1,367 people have been killed since April.
However, the true figure could be much higher, with the rebels saying they have lost at least 800 fighters and accusing the government of playing down its own losses.
Eighteen Ukrainian soldiers were killed and 54 injured in clashes on Tuesday, the government said.
The crisis erupted when well-armed pro-Russian gunmen took over various cities and attempted to break away from Ukraine. They have been slowly beaten back, and the fighting is now focused on the two rebel strongholds of Donetsk and Luhansk.
An air strike was carried out overnight on a suburb of Donetsk, residents and officials said, while the government denied being involved.
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