Iran has arrested 12 spies of the US Central Intelligence Agency (CIA), the official IRNA news agency reports.
Parviz Sorouri, an influential lawmaker, said the agents were targeting Iran's military and its nuclear programme.
He said they were operating in co-ordination with Israel's Mossad and other regional agencies.
The United States and its allies suspect Iran is pursuing a nuclear weapon program, a charge Tehran denies.
Mr Sorouri, a member of the powerful National Security and Foreign Policy Committee, did not give the nationality of the alleged agents, nor when they were arrested.
"The US and Zionist regime's espionage apparatuses were trying to use regional intelligence services, both inside and outside Iran, in order to deal a strong blow to our country," he was quoted as saying.
"Fortunately, these steps failed due to the quick measures taken by Intelligence Ministry officials," Mr Sorouri said.
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