Fifa president Sepp Blatter and vice-president Michel Platini have had their appeals against 90-day bans rejected by world football governing body's appeal committee.
They were suspended in October while Fifa's ethics committee investigates corruption claims against them.
Blatter, 79, is accused of signing a contract "unfavourable" to Fifa and making a "disloyal payment" to Platini.
Both deny wrongdoing and could appeal to the Court of Arbitration for Sport.
Fifa secretary general Jerome Valcke was also suspended in October but there was no mention of him in Wednesday's Fifa statement.
The adjudicatory panel of Fifa's ethics committee is due to hold hearings into the misconduct charges before Christmas.